Multi-Omics Mendelian Randomization Analysis for Glomerulonephritis Subtypes

A systematic multi-omics Mendelian randomization analysis by Guoqiang Li, published on figshare in April 2026. It integrates proteomic and transcriptomic quantitative trait loci with genome-wide association studies for four glomerulonephritis subtypes. The study identifies potential therapeutic targets and includes replication analysis using the FinnGen cohort.

Use Cases

• Identifying causal genes for glomerulonephritis subtypes based on proteomic-wide MR results like MTR and HCK
• Evaluating therapeutic potential for drug repositioning based on translational annotations of targets like IL6R and MBL2
• Strengthening causal inference for genetic targets using Bayesian colocalization analysis results for HCK, CD302, and TIMP4
• Comparing genetic architecture across GN subtypes using transcriptomic-wide MR candidate genes like RECQL, AFM, and IL6R

Strengths

• Integrates multiple omics layers (proteomic and transcriptomic QTLs) with GWAS data
• Includes independent replication and meta-analysis using the FinnGen cohort
• Applies downstream translational annotations including mouse knockout phenotypes and computational pharmacology
• Focuses on four specific GN subtypes: acute, chronic, IgA nephropathy, and membranous nephropathy

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• The dataset is 10.8 KB, indicating a very limited scope likely containing summary results rather than raw data

Provenance

Source

figshare

Collection Method

Systematic multi-omics Mendelian randomization analysis applying pQTL/eQTL resources to GWAS.

Freshness

Last updated 2026-04-16 17:46:12