DHFRs Aligned Using HHblits with Gaps Removed

134.2 KB of DHFR protein sequences aligned using HHblits with gaps removed for GEMME analysis. The dataset was created by Francois D. Rouleau and last updated on 2026-05-27. All sequences have less than 70% homology to PjDHFR to avoid skewing GEMME output with highly similar sequences.

Use Cases

• Train or evaluate protein fitness prediction models based on the curated multiple sequence alignment.
• Perform evolutionary conservation analysis based on the homology-filtered DHFR sequences.
• Benchmark multiple sequence alignment tools against the HHblits-processed data.

Strengths

• Sequences are filtered to have less than 70% homology to a reference, reducing redundancy.
• The dataset is shared under a CC-BY-4.0 license, permitting reuse with attribution.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.

Provenance

Source

figshare

Collection Method

Aligned using HHblits.

Freshness

Last updated 2026-05-27 17:44:14; freshness should be verified.