Diagnostic Criteria for Acute Neuroleptospirosis in Sri Lanka

From October 2021 to March 2024, an observational study collected diagnostic data from 100 patients with primary CNS infections in Sri Lanka. The dataset includes laboratory results from PCR and serology tests, clinical diagnoses, and patient outcomes. Author Nilanka Perera published the data via figshare.

Use Cases

• Identify patterns linking clinical diagnosis (meningitis, meningoencephalitis, encephalitis) to laboratory confirmation via PCR or MAT serology.
• Analyze the frequency of neurological symptoms like headache, seizures, and confusion among confirmed neuroleptospirosis cases.
• Compare clinical outcomes such as ICU requirement and mortality between neuroleptospirosis and other CNS infection groups.
• Investigate the association between positive Leptospira PCR results and the absence of CSF cellular reaction.

Strengths

• Includes data from 100 patients with detailed clinical and laboratory profiles.
• Provides a clear case definition using PCR and serology (MAT) results over a 2.5-year study period.
• Contains specific outcome metrics like ICU requirement and mortality for comparison between patient groups.

Limitations

• Small sample size of 100 total patients, with only 11 laboratory-confirmed neuroleptospirosis cases.
• Geographic scope is limited to three regions in Sri Lanka, limiting generalizability.
• Specific column names and data structure are not provided in the input.

Provenance

Source

Observational clinical study by author Nilanka Perera.

Collection Method

Patient recruitment and analysis of blood and cerebrospinal fluid via real-time PCR and microscopic agglutination test (MAT).

Time Range

October 2021 to March 2024

Freshness

Data covers up to March 2024 and was last updated on the platform in April 2026.

Geography

Three regions in Sri Lanka