Differential Gene Expression: Sudan Virus Vaccine Response in Macaques

Brianna M. Doratt published bulk RNA sequencing data from whole blood samples of nine cynomolgus macaques on figshare in April 2026. The dataset compares transcriptional responses to Sudan virus challenge after vaccination with VSV-SUDV or VSV-EBOV vaccines. Analysis was performed using EdgeR, STEM, MaSigPro, and CIBERSORTx to assess longitudinal changes.

Use Cases

• Analyzing longitudinal transcriptional changes in response to viral challenge based on bulk RNA sequencing data.
• Comparing protective versus non-protective vaccine responses based on the distinct transcriptional profiles described.
• Deconvolving immune cell frequency changes using in-silico methods like CIBERSORTx as mentioned in the description.
• Investigating the molecular mechanisms of rapid vaccine protection based on the 7-day pre-challenge vaccination group.

Strengths

• Data is from a controlled, longitudinal study with nine nonhuman primates.
• Analysis includes multiple established bioinformatics tools (EdgeR, STEM, MaSigPro, CIBERSORTx).
• Dataset is openly available under a CC-BY-4.0 license.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small at 314.9 KB, indicating limited scope.

Provenance

Source

Brianna M. Doratt via figshare.

Collection Method

Bulk RNA sequencing of whole blood samples from vaccinated and virus-challenged cynomolgus macaques.

Time Range

The study timeline is not specified.

Freshness

Last updated 2026-04-10 17:47:08.

Geography

Geographic origin of the data is not specified.