Julie Le Bris's dataset contains a list of differentially expressed genes (DGE) identified from capsule-swapped strains of Klebsiella pneumoniae compared to their native strains, using a |log2 fold-change| > 1 threshold. The data was last updated on March 25, 2026, and is shared under a CC-BY-4.0 license. It is a small dataset, stored in an XLSX file with a size of 30.2 KB.
Use Cases
- Identify candidate genes involved in host-pathogen interactions based on differential expression in capsule-swapped strains.
- Analyze the functional impact of capsule locus evolution based on gene expression changes.
- Validate hypotheses about specific pathways affected by polysaccharide capsule changes.
- Compare marginal fitness costs between different capsule types using gene expression signatures.
Strengths
- Data is focused on a specific biological comparison (capsule-swapped vs. native strains) with a defined statistical threshold (|log2 fold-change| > 1).
- Dataset is openly licensed (CC-BY-4.0) for reuse and redistribution.
- File is small (30.2 KB) and in a standard, accessible format (XLSX).
Limitations
- Row count and column-level documentation are unknown, which may limit suitability assessment.
- Description metadata is limited; actual data quality and structure require manual inspection after download.
Provenance
- Source
- figshare, author Julie Le Bris
- Collection Method
- Likely derived from comparative genomic or transcriptomic analysis of bacterial strains.
- Time Range
- null
- Freshness
- Last updated 2026-03-25 17:39:23; freshness should be verified.
- Geography
- null