Differentially Expressed Genes in L. major Cell Lines with FDR Correction

Lists of differentially expressed genes from comparisons of AV, V, AVM, and AVS cell lines of the parasite Leishmania major Friedlin. The dataset includes genes identified with an FDR-adjusted p-value cut-off of 0.001 and a minimum absolute fold change greater than 2, annotated using the TriTrypDB genome resource. It was authored by Evgeny S. Gerasimov and last updated on May 29, 2026.

Use Cases

• Identify potential drug targets based on genes differentially expressed in virulent versus avirulent cell lines.
• Validate gene expression markers for specific Leishmania major phenotypes mentioned in the description.
• Perform pathway over-representation analysis using the Fisher's exact test results described.
• Compare gene expression patterns across multiple experimental conditions (V vs AV, AVM vs AV, AVS vs AV).

Strengths

• Applies a stringent statistical threshold with an FDR-adjusted p-value cut-off of 0.001.
• Filters results by a minimum absolute fold change greater than 2, focusing on biologically significant changes.
• Uses annotations from the authoritative TriTrypDB Leishmania major Friedlin genome.
• Highlights genes found to be differentially expressed in multiple sample comparisons.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is small at 49.9 KB, indicating a limited scope of results.

Provenance

Source

figshare

Collection Method

Differential expression analysis from cell line comparisons, with statistical analysis by one-sided Fisher’s exact test and Benjamini-Hochberg FDR correction.

Freshness

Last updated 2026-05-29 17:29:28; freshness should be verified.