Down and Up-regulated Genes at 24h in Streptomyces clavuligerus with BldD Overexpression

Luisa F. Patiño's transcriptomic dataset compares a Streptomyces clavuligerus strain overexpressing the bldD gene to a control strain during fermentation. The data, last updated in April 2026, captures gene expression changes at 24 hours, focusing on impacts on antibiotic and terpene biosynthesis pathways. The 36.1 KB XLSX file contains results from a study investigating the global regulator BldD's role in metabolic redirection and morphological development.

Use Cases

• Identify differentially expressed genes related to cephamycin C and clavulanic acid biosynthesis based on the described repression.
• Analyze upregulated pathways for terpene biosynthesis and phage tail-like particle (CIS) genes mentioned in the description.
• Investigate gene expression links between the bldD regulator and morphological development genes like bldN, bldM, and chaplins.
• Study metabolic flux redirection in Streptomyces based on transcriptomic changes at a 24-hour time point.

Strengths

• Data is focused on a specific, well-defined biological comparison between a genetically modified strain and a control.
• The description provides clear biological context for the observed gene expression changes, linking them to specific pathways.
• Dataset is openly licensed under CC-BY-4.0, facilitating reuse and sharing.

Limitations

• Row count is unknown, which may limit suitability assessment for large-scale analysis.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small at 36.1 KB, indicating limited scope, likely containing only summary results rather than raw sequencing data.

Provenance

Source

figshare, authored by Luisa F. Patiño.

Collection Method

Transcriptomic analysis (likely RNA-seq) of Streptomyces clavuligerus strains during fermentation in soy protein isolate medium.

Time Range

Single time point measurement at 24 hours of fermentation (a 72h time point is mentioned in the study but not necessarily in this specific file).

Freshness

Last updated 2026-04-22 17:27:48; freshness should be verified.

Geography

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