Efficiency of Induced Gene Deletion in Candida albicans

Inducible gene deletion experiments assessed the essentiality of protein kinases for growth and viability in the pathogenic yeast Candida albicans. The 9.5 KB XLS file, authored by Bernardo Ramírez-Zavala and last updated in April 2026, contains results identifying viable but slow-growing mutants and lethal deletions affecting septin organization and cytokinesis. Findings suggest Candida albicans uses a septation initiation network (SIN) for septum formation.

Use Cases

• Identify essential protein kinases in Candida albicans based on deletion mutant viability data.
• Analyze growth phenotypes and suppressor mutations based on results from ptk2Δ mutants.
• Study septin organization and cytokinesis defects based on phenotypes of orf19.5376 and orf19.3456 mutants.
• Investigate candidate kinase regulatory subunits based on co-immunoprecipitation and mass spectrometry results mentioned for orf19.193.

Strengths

• Data is licensed under CC-BY-4.0, permitting open sharing and adaptation.
• File size is precisely 9.5 KB, indicating a compact and focused dataset.
• Specific experimental results are described, including mutants like bud32Δ, ctk1Δ, rio1Δ, rio2Δ, PTK2, orf19.5376, and orf19.3456.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare

Collection Method

Inducible gene deletion experiments in Candida albicans, likely followed by phenotypic analysis and co-immunoprecipitation with mass spectrometry.

Time Range

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Freshness

Last updated 2026-04-21 17:46:36; freshness should be verified.

Geography

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