Paraben-HNSCC Hub Gene Enrichment and Docking Analysis

A 2026 study by Lei Zhao provides molecular docking and enrichment analysis results for 12 hub genes (e.g., CCNB1, CDK1, CCNA2) linked to head and neck squamous cell carcinoma (HNSCC) and paraben exposure. The dataset contains results from integrated network toxicology, including binding affinities and immune infiltration correlations. It is derived from public databases like TCGA-HNSC and Swiss Target Prediction.

Use Cases

• Analyze the binding affinity scores from molecular docking between six parabens and 12 hub gene proteins like CCNA1.
• Investigate the correlation between CCNA1 expression levels and immune cell infiltration metrics (e.g., CD8+ T cell, B cell).
• Validate the functional enrichment results for hub genes in pathways like cell cycle regulation and p53 signaling.
• Examine the overexpression patterns of identified hub genes (e.g., CCNB1, CDK1) in HNSCC tissue data.

Strengths

• Focuses on 12 specific hub genes validated through multiple analytical methods.
• Integrates data from several authoritative sources including TCGA-HNSC, GeneCards, and STRING.
• Includes results from molecular docking simulations for six common parabens.

Limitations

• Very small data volume at 33.8 KB, indicating limited scope and likely summary-level results.
• Contains no raw gene expression or patient-level data, only processed analysis outputs.
• Temporal coverage and sample sizes for underlying data are not specified in the provided description.

Provenance

Source

Analysis derived from public databases including TCGA-HNSC, GeneCards, OMIM, CTD, Swiss Target Prediction, ChEMBL.

Collection Method

Integrated network toxicology and molecular docking analysis performed by the author.

Freshness

Last updated in March 2026.