ERG Annotation: Prioritized Cancer-Associated Epigenetic Regulator Genes

A list of cancer-associated epigenetic regulators (cERs) prioritized by the CASER machine-learning model. The dataset was created by Hao Li and last updated on April 28, 2026. It integrates multi-omics features including mutational, genomic, epigenetic, and transcriptomic data.

Use Cases

• Prioritizing novel cancer driver genes based on integrated multi-omics features.
• Identifying potential therapeutic targets based on associations with anti-cancer medicines.
• Classifying epigenetic regulators into functional subtypes for mechanistic studies.
• Benchmarking new predictive models for cancer-associated gene identification.

Strengths

• Integrates a wide range of multi-omics-derived features as described.
• Demonstrated predictive performance against an independent gene set as noted in the study.
• Identified six candidate cERs shown to alter cell proliferation in four cancer cell lines.
• Released under a permissive CC-BY-4.0 license.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is small in scale at 62.1 KB, indicating a limited list of genes.

Provenance

Source

figshare, author Hao Li.

Collection Method

Generated via the semi-supervised CASER machine-learning model.

Time Range

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Freshness

Last updated 2026-04-28 17:49:26; freshness should be verified.

Geography

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