Evolutionary Conservation Profiles of Pathogenic Single Nucleotide Polymorphisms

Arwa Ibrahim Alwabran published a dataset of evolutionary conservation profiles for pathogenic nonsynonymous single nucleotide polymorphisms (nsSNPs). The dataset is stored in an XLS file of 5.5 KB and was last updated on May 21, 2026. It is licensed under CC-BY-4.0.

Use Cases

• Predicting variant pathogenicity based on evolutionary conservation profiles mentioned in the description.
• Training machine learning models for variant prioritization using conservation scores.
• Benchmarking new conservation scoring algorithms against a set of known pathogenic variants.
• Analyzing the relationship between evolutionary pressure and disease-causing mutations.

Strengths

• Dataset is openly licensed under CC-BY-4.0.
• File size is 5.5 KB, indicating a focused and manageable dataset.
• Last update timestamp is provided (2026-05-21 17:28:57).

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

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