Cytokine Data from Ex Vivo Pertussis Infection Model in Cord and Adult Blood

Excel files containing cytokine and multi-omic data from an ex vivo whole-blood infection model comparing neonatal and adult immune responses to Bordetella pertussis. The dataset, authored by Soraya Matczak and last updated in April 2026, is shared under a CC-BY-4.0 license on figshare. Its 20.8 KB size indicates a focused, rather than large-scale, experimental dataset.

Use Cases

• Compare pro-inflammatory cytokine signatures between cord blood and adult blood based on the described hyperinflammatory response.
• Analyze B cell remodeling and activation marker expression based on the described CD25+ B lymphocyte phenotype.
• Investigate transcriptomic signatures of innate immune cell activation based on the whole-blood analysis mentioned.
• Study the role of myeloid-derived suppressor cells in early infection based on their reported early loss in cord blood.

Strengths

• Data originates from a controlled ex vivo infection model, a method highlighted as addressing a research gap.
• Includes multi-omic profiling, likely combining cytokine measurements with transcriptomic data as described.
• Provides a direct comparison between two distinct biological groups: cord blood and adult blood.

Limitations

• Row count is unknown, which may limit suitability assessment for statistical modeling.
• Column-level documentation is absent; field semantics must be inferred after download.
• The 20.8 KB file size suggests a very limited scope, potentially containing summary results rather than raw, high-dimensional data.

Provenance

Source

figshare, author Soraya Matczak.

Collection Method

Data generated from an ex vivo whole-blood infection model with Bordetella pertussis, followed by multi-omic profiling.

Time Range

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Freshness

Last updated 2026-04-22 17:38:55; freshness should be verified.

Geography

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