Experimental Data Underlying Figures 1 Through 5

Tyrosine kinase inhibitors (TKI) were tested for their ability to inhibit nucleoside and nucleobase transporters ENT1, ENT2, and ENBT1 in genetically modified HEK293 and K562 cell lines. The dataset, authored by Nayyar Shahid and shared under a CC-BY-4.0 license, contains the experimental results supporting five figures in the associated research. All tested TKI inhibited ENT1 and ENT2 with Ki values ranging from 1 to 30 µM.

Use Cases

• Analyzing TKI inhibition potency based on Ki values for different transporters.
• Comparing transporter inhibition profiles (ENT1 vs ENT2 vs ENBT1) across a series of TKI drugs.
• Investigating the relationship between transporter expression and drug efficacy in cell viability assays.
• Supporting computational modeling of drug-transporter interactions using the provided experimental inhibition data.

Strengths

• Data is derived from controlled experiments using genetically modified cell lines to isolate specific transporter activity.
• Inhibition affinities (Ki values) are quantified, providing a precise measure of drug-transporter interaction.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for large-scale analysis.

Provenance

Source

figshare

Collection Method

Experimental data from in vitro assays on HEK293 and K562 cell lines.

Freshness

Last updated 2026-05-15 17:29:13; freshness should be verified.