EBV Lytic Gene Expression Time Course Data from HH514-16 Cells

RT-qPCR data for four genes (BZLF1, BGLF5, ELAVL4, PABPC4L) measured at five time points (8, 12, 18, 24, and 48 hours) after treatment of HH514-16 cells with TSA or AzaCdR. The dataset, shared by Derek Daigle on figshare under a CC-BY-4.0 license, shows expression levels relative to untreated controls. The data file is 5.5 KB in size and was last updated in May 2026.

Use Cases

• Modeling the kinetic relationship between viral and cellular gene expression based on time-series measurements.
• Analyzing the effect of epigenetic modulators (TSA, AzaCdR) on EBV lytic cycle progression.
• Validating thresholds for significant gene expression changes using the described 2-fold over background criterion.

Strengths

• Data includes measurements at five distinct time points (8, 12, 18, 24, 48 hours), enabling kinetic analysis.
• Expression values are provided relative to untreated controls, facilitating direct comparison.
• Dataset is openly shared under a permissive CC-BY-4.0 license.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is very small (5.5 KB), indicating a limited scope focused on a specific experimental result.

Provenance

Source

Derek Daigle

Collection Method

Total RNA was extracted from HH514-16 cells treated with TSA or AzaCdR, followed by RT-qPCR analysis.

Time Range

Measurements taken from 8 to 48 hours post-treatment.

Freshness

Last updated 2026-05-11 17:46:07; freshness should be verified.