Fibrosis Scores Across Experimental Groups in a Rat Liver Study

Fibrosis scores across experimental groups is a dataset from a study investigating the effects of calcitriol on diethylnitrosamine-induced liver fibrosis in a rat model. The dataset, authored by Komsan Arramrak and last updated in May 2026, contains results from biochemical assays, immunohistochemistry, qRT-PCR, and western blotting. It is a small dataset of 5.5 KB, stored in an XLS file.

Use Cases

• Analyzing the dose-dependent effects of calcitriol on oxidative stress based on hepatic malondialdehyde levels.
• Comparing liver injury markers like serum ALT and AST across control and treatment groups.
• Investigating the relationship between antioxidant gene expression (SOD-1, GPX-1) and fibrosis attenuation.
• Evaluating the suppression of inflammatory and fibrogenic signaling based on NF-κB p65 and TGF-β1 levels.
• Correlating histopathological fibrosis scores with molecular markers such as α-SMA and collagen.

Strengths

• Data is derived from a controlled experimental design with four distinct groups (n=6/group).
• Multiple measurement techniques were used, including biochemical assays, qRT-PCR, and histopathology.
• Dataset is openly available under a CC-BY-4.0 license.
• Specific intervention doses (5 µg/kg and 10 µg/kg calcitriol) and induction protocol (70 mg/kg DEN for 8 weeks) are documented.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Dataset is very small (5.5 KB), indicating limited scope or summary-level data.

Provenance

Source

Komsan Arramrak via figshare

Collection Method

Data generated from a controlled animal study involving Sprague-Dawley rats.

Time Range

Experimental period involved 8 weeks of DEN injections.

Freshness

Last updated 2026-05-06 17:38:13; freshness should be verified.

Geography

Laboratory study; geographic location is unknown.