LT-HT Rat Hippocampus RNA Sequencing Data

18.5 KB of bulk RNA sequencing data from the hippocampus of two rat strains bred for contrasting neural excitability thresholds. Marina Pavlova published this transcriptomic reference profile on figshare in June 2026 under a CC-BY-4.0 license. The analysis reveals strain-specific transcriptional profiles involving synapse-related genes, glial/immune functions, and cellular maintenance pathways.

Use Cases

• Cross-model comparisons of excitability-related traits based on the reference transcriptomic profile.
• Hypothesis testing for synaptic and neurite organization based on differential expression of synapse- and plasticity-related genes.
• Evaluation of cellular maintenance pathways based on identified differences in MAPK/PI3K-linked trafficking and redox regulation.
• Analysis of glial and neurovascular components based on strain-specific non-neuronal transcriptional profiles.

Strengths

• 18.5 KB of data provides a focused transcriptomic reference profile.
• Data originates from a long-term selective-breeding paradigm, a recognized model for studying inherited differences.
• The description details specific functional annotation categories like synaptic organization and neuronal projection development.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small (18.5 KB), indicating limited scope.

Provenance

Source

figshare

Collection Method

Bulk RNA sequencing of hippocampus tissue from selectively bred rat strains.

Freshness

Last updated 2026-06-03 17:37:34; freshness should be verified.