Fig 5 String Node Degrees: Hippocampus RNA-seq in High- and Low-Excitability Rats

7.3 KB of bulk RNA sequencing data from the hippocampus of two selectively bred rat strains, high-excitability (LT) and low-excitability (HT), generated by Marina Pavlova. The dataset provides a transcriptomic reference for polygenic excitability traits, highlighting differences in synaptic, glial, and cellular maintenance pathways.

Use Cases

• Identify differentially expressed genes related to neural excitability based on strain-specific transcriptional profiles.
• Analyze pathways involved in synaptic organization and neuronal projection development based on functional annotation.
• Investigate non-neuronal components such as glial/immune functions and extracellular matrix remodeling mentioned in the description.
• Generate hypotheses for follow-up structural and functional tissue-level measurements involving MAPK/PI3K-linked trafficking and redox regulation.
• Compare transcriptomic profiles from long-term selective-breeding paradigms with other models of polygenic traits.

Strengths

• Data is openly available under a CC-BY-4.0 license.
• The dataset is derived from a controlled model of selectively bred rat strains with contrasting neural excitability.
• The description details specific biological pathways and components investigated, such as synapse-related genes and glial/immune functions.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small (7.3 KB), indicating limited scope or a subset of results.

Provenance

Source

Marina Pavlova via figshare.

Collection Method

Bulk RNA sequencing of hippocampus tissue from selectively bred rat strains.

Freshness

Last updated 2026-06-03 17:37:36; freshness should be verified.