LT and HT Rat Hippocampus RNA-Seq Data for Excitability Traits

Fig 6 string MCL cluster descriptions dataset contains bulk RNA sequencing data from the hippocampus of high-excitability (LT) and low-excitability (HT) rat strains. The data was generated by Marina Pavlova and is available on figshare under a CC-BY-4.0 license. It provides a transcriptomic reference for studying polygenic excitability-related traits.

Use Cases

• Comparative transcriptomic analysis based on strain-specific expression profiles.
• Investigating synaptic organization and neuronal projection development based on differential expression of related genes.
• Studying glial/immune functions and neurovascular regulation based on highlighted non-neuronal components.
• Evaluating cellular maintenance pathways like MAPK/PI3K-linked trafficking and redox regulation.
• Cross-model comparisons of excitability traits based on the reference transcriptomic profile from selective breeding.

Strengths

• Dataset is openly available under a CC-BY-4.0 license.
• Data is derived from a long-term selective-breeding paradigm, providing a specific model for inherited traits.
• The description details specific biological processes investigated, such as synaptic organization and glial functions.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is 27.0 KB, indicating a very limited scope of data.

Provenance

Source

Marina Pavlova

Collection Method

Bulk RNA sequencing of hippocampus tissue from selectively bred rat strains.

Freshness

Last updated 2026-06-03 17:37:37; freshness should be verified.