HIV-1 Infectivity and p24 Secretion Correlation Data

A 3.5 MB Excel dataset contains results from a high-content imaging reporter assay using modified GHOST cells to study HIV-1 replication dynamics. The assay correlates viral infectivity with p24 secretion in supernatants, enabling deeper interrogation of infection kinetics. The data was authored by Teresa LuPone and last updated in March 2026.

Use Cases

• Analyze the correlation between HIV-1 infectivity measurements and p24 secretion levels from collected supernatants.
• Use the high-content imaging reporter assay data to model HIV-1 replication dynamics in distinct cell populations.
• Benchmark viral infectivity and tropism using the modified GHOST cell fluorescence response data.
• Investigate the impact of Antiretroviral Therapy (ART) on the proportion of non-infectious virions using the assay results.

Strengths

• Data originates from a peer-reviewed scientific methodology using a modified high-content imaging reporter assay.
• Assay is designed for rapid evaluation of large sample numbers with consistency and replicability.
• Dataset is shared under a permissive CC BY 4.0 license, facilitating reuse.

Limitations

• The dataset is small at 3.5 MB, which may limit the scope of statistical or machine learning analysis.
• Specific sample size (row count) and measured variables (columns) are not provided in the metadata.
• Data is focused on a specific experimental cell line (GHOST cells), which may not represent all in vivo conditions.

Provenance

Source

figshare, authored by Teresa LuPone.

Collection Method

High-content imaging reporter assay using modified human osteosarcoma (GHOST) cells expressing HIV-1 receptors.

Time Range

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Freshness

Last updated March 2026.

Geography

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