FIMO Results: Transcriptomic Data from Streptomyces clavuligerus BldD Overexpression Study

Transcriptomic analyses from a 2026 study comparing a Streptomyces clavuligerus strain overexpressing the bldD regulator with a control strain during fermentation. The dataset, published by Luisa F. Patiño under CC-BY-4.0, contains results from samples taken at 24 and 72 hours, showing changes in gene expression related to antibiotic biosynthesis and morphological development.

Use Cases

• Analyze the regulatory impact of BldD on cephamycin C and clavulanic acid biosynthesis pathways based on transcriptomic data.
• Investigate the relationship between BldD overexpression and upregulated genes for terpene biosynthesis and phage tail-like particles (CIS).
• Study the link between metabolic flux redirection and morphological differentiation genes like bldN, bldM, and chaplins.
• Compare species-specific regulatory mechanisms in S. clavuligerus with the model organism S. coelicolor.

Strengths

• Data is from a controlled experiment with defined time points (24h and 72h) and strain comparisons.
• Published under a permissive CC-BY-4.0 license for reuse.
• Focuses on a specific, less-understood regulator (BldD) in a wild-type Streptomyces strain.

Limitations

• The dataset is very small at 1.3 KB, suggesting limited scope or summary-level data.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for statistical modeling.

Provenance

Source

figshare

Collection Method

Transcriptomic analysis of genetically modified and control Streptomyces clavuligerus strains during fermentation.

Time Range

Samples collected at 24 and 72 hours during fermentation.

Freshness

Last updated 2026-04-22 17:27:50.

Geography

Laboratory study; geographic origin not specified.