Fine-mapping Analyses: Prioritized SNPs for Age-Related Eye Disease

A genetic study by Luqi Gao, last updated in May 2026, identifies candidate genetic variants for Age-related eye disease (ARED). The analysis used Genomic Structural Equation Modeling (Genomic-SEM) and post-processing of Genome-Wide Association Studies (GWAS) data. It reports 11 genome-wide significant loci and includes functional annotations of tissue- and cell layer-associated gene signals.

Use Cases

• Prioritizing candidate single nucleotide polymorphisms (SNPs) for further experimental validation based on GWAS post-processing results.
• Analyzing tissue- and cell layer-specific gene expression signals related to ocular vulnerabilities.
• Conducting functional annotation of genetic loci associated with Age-related eye disease (ARED).
• Applying transcriptome-wide association study (TWAS) approaches to identify gene-trait associations.

Strengths

• Identifies 11 genome-wide significant loci for Age-related eye disease (ARED).
• Applies multiple analytical methods, including Genomic-SEM and diverse transcriptome-wide association approaches.
• Released under a permissive CC-BY-4.0 license for open reuse.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small at 11.4 KB, indicating limited scope.

Provenance

Source

figshare, author Luqi Gao

Collection Method

Genomic Structural Equation Modeling (Genomic-SEM) and post-processing analysis of Genome-Wide Association Studies (GWAS).

Freshness

Last updated 2026-05-14 17:48:50; freshness should be verified.