Cryptococcus Neoformans CO2 Tolerance Genetic Screen Results

301 of 4,692 deletion mutants showed altered CO2 tolerance in a near genome-wide competitive growth assay. The dataset, authored by Laura C. Ristow and updated in 2026, provides a genetic profile of how this environmental fungal pathogen adapts to host conditions. It supports a model linking CO2 stress to metabolic remodeling, oxidative stress, and membrane homeostasis.

Use Cases

• Identify genetic determinants of CO2 tolerance in Cryptococcus neoformans based on the competitive growth assay results.
• Model integrated stress responses linking metabolism, oxidative stress, and membrane homeostasis based on the described genetic and metabolomic analysis.
• Prioritize candidate genes for virulence studies based on the 245 mutants with reduced fitness under host CO2 conditions.

Strengths

• Results from a near genome-wide screen covering 4,692 deletion mutants.
• 301 specific mutants with altered CO2 tolerance are identified (245 reduced, 56 increased fitness).
• Openly licensed under CC-BY-4.0 for reuse and redistribution.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for certain analyses.
• The 11.4 KB file size suggests a limited, summary-level dataset rather than raw experimental data.

Provenance

Source

figshare, authored by Laura C. Ristow.

Collection Method

Competitive growth assay for deletion mutants of Cryptococcus neoformans.

Time Range

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Freshness

Last updated 2026-05-05 17:37:22; freshness should be verified.

Geography

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