FOCUS: Fine-Mapped Genetic Loci for Age-Related Eye Disease

Luqi Gao's research presents a genetic landscape for Age-related eye disease (ARED) using Genomic Structural Equation Modeling and post-GWAS analysis. The study identified 11 genome-wide significant loci and analyzed tissue- and cell layer-associated gene signals. The dataset was last updated on May 14, 2026.

Use Cases

• Prioritizing candidate SNPs for functional validation based on fine-mapping results.
• Investigating tissue-specific gene expression signals related to age-related ocular vulnerabilities.
• Conducting functional annotation of genetic variants associated with independent ARED variants.

Strengths

• Identifies 11 genome-wide significant loci for Age-related eye disease.
• Applies multiple transcriptome-wide association approaches for functional analysis.
• Dataset is openly available under a CC-BY-4.0 license.

Limitations

• Dataset is very small at 10.7 KB, indicating limited scope.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

figshare, author Luqi Gao

Collection Method

Generated using Genomic Structural Equation Modeling (Genomic-SEM) and post-processing of Genome-Wide Association Studies.

Freshness

Last updated 2026-05-14 17:48:53; freshness should be verified.