Gene Lists: Hippocampal RNA Sequencing in High- and Low-Excitability Rat Strains

RNA sequencing data from the hippocampus of selectively bred rat strains contrasts high-excitability (LT) and low-excitability (HT) thresholds. Marina Pavlova authored this transcriptomic reference profile for studying polygenic excitability traits. The dataset was last updated on June 3, 2026.

Use Cases

• Identify strain-specific transcriptional profiles based on differential expression analysis mentioned in the description
• Analyze differences in synaptic organization and neuronal projection development based on functional annotation
• Investigate glial/immune functions and neurovascular regulation highlighted in the transcriptomic divergence
• Evaluate cellular maintenance pathways such as MAPK/PI3K-linked trafficking and redox regulation
• Perform cross-model comparisons of excitability-related traits using the reference transcriptomic profile

Strengths

• Dataset is openly licensed under CC-BY-4.0
• Focuses on a specific, genetically defined model (LT and HT rat strains)
• Analysis includes functional annotation of transcriptomic differences

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• The dataset is small, at 242.7 KB, indicating limited scope

Provenance

Source

figshare

Collection Method

Bulk RNA sequencing of hippocampus tissue from selectively bred rat strains

Freshness

Last updated 2026-06-03 17:37:33; freshness should be verified