Gene Expression in ATG5 and ATG7-Silenced Endothelial Cells from a TGF-ß/BMP PCR Array

Gene expression data for endothelial cells where the autophagy genes ATG5 and ATG7 have been silenced. The dataset lists genes down-regulated in ATG5-silenced cells compared to controls and indicates their status in ATG7-silenced cells. Data was collected by Aman Singh 24 hours post-transfection using a TGF-ß/BMP signaling pathway PCR array and is shared under a CC-BY-4.0 license.

Use Cases

• Identify candidate genes regulated by autophagy in endothelial cells based on the ATG5/ATG7 silencing experiment.
• Compare the effects of silencing two different autophagy genes (ATG5 vs. ATG7) on shared signaling pathways.
• Validate or generate hypotheses about the role of specific TGF-ß/BMP pathway genes in autophagy processes.

Strengths

• Data is focused on a specific biological mechanism (autophagy) and pathway (TGF-ß/BMP).
• Experimental conditions (24 hours post-transfection) are clearly stated.
• Shared under a permissive CC-BY-4.0 license allowing reuse and modification.

Limitations

• Dataset is very small at 5.5 KB, indicating limited scope.
• Row count and column-level documentation are unknown, requiring manual inspection after download.
• Description metadata is limited; actual data quality and completeness require verification.

Provenance

Source

figshare, author Aman Singh.

Collection Method

Data collected 24 hours post-transfection using a TGF-ß/BMP signaling pathway PCR array.

Time Range

Single time point measurement (24 hours post-transfection).

Freshness

Last updated 2026-04-30 17:34:29; freshness should be verified.

Geography

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