Genome-wide sgRNA Scores from a Synthetic-Viability CRISPR Screen (HNRNPK vs. NT)

9.4 MB of sgRNA scores from a genome-wide synthetic-viability CRISPR screen comparing HNRNPK to a non-targeting control at day 14. The dataset, authored by Stefano Sellitto and last updated in April 2026, includes sgRNAs classified as significantly enriched or depleted based on applied thresholds. It is shared under a CC-BY-4.0 license on figshare.

Use Cases

• Identify significantly enriched or depleted sgRNAs based on the applied thresholds mentioned in the description
• Analyze genome-wide distribution patterns of sgRNA scores from a synthetic-viability screen
• Compare genetic perturbation effects between HNRNPK knockdown and non-targeting control conditions
• Validate or benchmark statistical methods for classifying sgRNA hits in CRISPR screens

Strengths

• Data is focused on a specific biological comparison (HNRNPK vs. NT at day 14)
• File size is 9.4 MB, indicating a manageable download and analysis scale
• Includes sgRNAs classified as significantly enriched or depleted, providing a filtered subset for analysis

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• Description metadata is limited; actual data quality requires manual inspection after download

Provenance

Source

figshare

Collection Method

Likely generated from a CRISPR-based synthetic-viability screen.

Time Range

The screen comparison is specified at day 14.

Freshness

Last updated 2026-04-20 17:40:23; freshness should be verified

Geography

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