Genomic Positions for Influenza H3 Antigenic Sites from Household Transmission Study

Genomic positions for H3 antigenic sites from a study of influenza A virus evolution in acute infections and household transmission. The dataset is associated with a study of 384 children and household contacts with RT-PCR-confirmed influenza A infection from 2017–19, investigating A(H1N1)pdm09 and A(H3N2) viruses. It was authored by Hunter J. Ries and last updated on figshare in May 2026.

Use Cases

• Mapping antigenic site locations on the hemagglutinin (HA) protein based on genomic positions.
• Analyzing selection pressures on antigenic regions during acute infection and transmission events.
• Investigating the role of transmission bottlenecks in influenza virus evolution.
• Comparing genomic variation in A(H1N1)pdm09 and A(H3N2) viruses from the 2017-19 period.

Strengths

• Data is derived from a study of 384 individuals with confirmed influenza A infection.
• Focuses on 40 identified transmission events across 31 households.
• Published under a permissive CC-BY-4.0 license.

Limitations

• Dataset is very small at 13.5 KB, indicating limited scope.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

figshare, authored by Hunter J. Ries.

Collection Method

Leveraged a large household cohort study with specimens from RT-PCR-confirmed infections.

Time Range

Associated with infections from 2017–19.

Freshness

Last updated 2026-05-07 17:42:32; freshness should be verified.

Geography

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