GP Long: Long-Term Visual Acuity Trajectories in Japanese LHON Patients

Yasuyuki Takai's dataset contains longitudinal visual acuity data for a cohort of patients with Leber hereditary optic neuropathy (LHON). It includes best-corrected visual acuity (BCVA, logMAR) measurements from onset to 120 months for 53 eyes from 27 patients, collected in a single-center retrospective study at a tertiary eye hospital in Japan. The data was last updated on 2026-04-28.

Use Cases

• Modeling long-term visual acuity trajectories based on piecewise linear phases described in the study.
• Estimating cumulative probabilities of achieving specific BCVA thresholds (e.g., ≤1.6 logMAR) over a decade.
• Comparing disease progression patterns between different genetic subgroups, such as the m.11778G>A variant.
• Benchmarking clinical outcomes for rare diseases with limited long-term follow-up data.

Strengths

• Contains 10 years of continuous follow-up data for a rare disease cohort, which is uncommon.
• Data is derived from 174 genetically confirmed LHON patients, with a subset of 27 patients (53 eyes) meeting strict inclusion criteria.
• Visual acuity is measured using a standardized metric (BCVA logMAR).
• Analysis includes phase-specific statistical models (Acute, Chronic, Late Chronic) with confidence intervals.

Limitations

• The sample size is modest (27 patients, 53 eyes), limiting statistical power for subgroup analyses.
• Column-level documentation is absent; field semantics must be inferred after download.
• Data may reflect selection bias inherent to long-term attendees at a single tertiary center in Japan.

Provenance

Source

Yasuyuki Takai via figshare.

Collection Method

Single-center retrospective cohort study at a tertiary eye hospital in Japan.

Time Range

Follow-up data spans from disease onset to 120 months (10 years).

Freshness

Last updated 2026-04-28 17:27:00; freshness should be verified.

Geography

Data originates from a patient cohort in Japan.