<p>GRADE certainty of evidence.</p>

Ismaila Ajayi Yusuf's dataset contains the results of a systematic review and network meta-analysis comparing aldosterone synthase inhibitors for hypertension. The analysis includes 7 randomized controlled trials with 2,828 participants, evaluating systolic and diastolic blood pressure reductions and safety outcomes. The dataset was last updated on June 3, 2026, and is stored in an XLS file.

Use Cases

• Compare the efficacy of baxdrostat, lorundrostat, and LCI699/osilodrostat based on systolic blood pressure reduction data.
• Analyze safety outcomes like hypotension and hyperkalemia risk based on relative risk (RR) figures.
• Model phenotype-specific treatment effects based on subgroup analyses for resistant versus uncontrolled hypertension.

Strengths

• Analysis is based on 7 randomized controlled trials with a total of 2,828 participants.
• Includes specific quantitative results, such as blood pressure reductions in mmHg and relative risks for adverse events.
• Adheres to PRISMA guidelines and is registered in PROSPERO (CRD420251266257).

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small at 5.5 KB, indicating limited scope.

Provenance

Source

figshare

Collection Method

Systematic review and network meta-analysis of randomized trials from PubMed/MEDLINE, Scopus, Embase, ClinicalTrials.gov, and Cochrane Library.

Time Range

Literature search from database inception to January 14, 2026.

Freshness

Last updated 2026-06-03 17:45:51; freshness should be verified.

Geography

Global (trials likely international, but not specified).