GSEA Results for Potential Key Genes in Diabetic Retinopathy

Gene set enrichment analysis results for two potential key genes, MMP15 and FOXK1, identified in a study of uric acid-related genes in diabetic retinopathy. The dataset was authored by Haiming Liang and uploaded to figshare on 2026-06-02. It includes results from immune infiltration analysis and transcription factor targeting.

Use Cases

• Validate potential biomarkers for diabetic retinopathy based on the identified genes MMP15 and FOXK1.
• Investigate immune cell correlations in diabetic retinopathy based on the analysis of 7 immune cell types.
• Study gene regulatory networks based on the 12 transcription factors identified as targeting both key genes.
• Explore molecular pathways like the phosphatidylinositol signaling system based on the gene set enrichment results.

Strengths

• Includes results from multiple analytical methods: differential expression, machine learning, ROC analysis, and GSEA.
• Contains specific findings, such as correlations with 7 immune cell types and identification of 12 transcription factors.
• Clinical validation was performed using RT-qPCR on patient blood samples.

Limitations

• Row count and column-level documentation are unknown, which limits suitability assessment.
• The dataset is small at 483.0 KB, indicating limited scope.
• Description metadata is limited; actual data structure and quality require manual inspection after download.

Provenance

Source

figshare, author Haiming Liang.

Collection Method

Generated from public database transcriptome data using differential expression analysis, machine learning, and subsequent bioinformatics analyses.

Freshness

Last updated 2026-06-02 17:32:45; freshness should be verified.