GWAS Subtraction Sites: Prioritized SNPs for Age-Related Eye Disease

11 genome-wide significant loci were identified for Age-related eye disease (ARED) using Genomic Structural Equation Modeling. Luqi Gao published this genetic landscape analysis on figshare in May 2026, presenting statistically prioritized candidate single nucleotide polymorphisms. The research analyzed tissue-, cell layer-, and genomic element-associated gene signals to reflect age-related ocular vulnerabilities.

Use Cases

• Prioritizing candidate genes for functional validation based on statistically prioritized SNPs.
• Analyzing tissue-specific gene expression signals in relation to age-related ocular vulnerabilities.
• Studying the genetic architecture of complex traits using Genomic Structural Equation Modeling (Genomic-SEM) results.
• Conducting transcriptome-wide association studies (TWAS) using the identified loci as a starting point.

Strengths

• Identifies 11 genome-wide significant loci for Age-related eye disease.
• Applies multiple transcriptome-wide association approaches for functional annotation.
• Published under a permissive CC-BY-4.0 license for reuse.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is very small (14.9 KB), suggesting limited scope or a summary-level dataset.

Provenance

Source

figshare

Collection Method

Genomic Structural Equation Modeling (Genomic-SEM) and Post-processing analysis of Genome-Wide Association Studies (GWAS).

Freshness

Last updated 2026-05-14 17:48:49; freshness should be verified.