Heritability Contribution at Genomic Regions for Age-Related Eye Disease

Luqi Gao's dataset presents genetic analysis results for Age-Related Eye Disease (ARED). It contains 11 genome-wide significant loci identified using Genomic Structural Equation Modeling and post-processing of GWAS data. The research, last updated in May 2026, provides a genetic landscape for ARED.

Use Cases

• Prioritizing candidate SNPs for functional validation based on statistical significance from GWAS.
• Analyzing tissue- and cell layer-specific gene signals associated with age-related ocular vulnerabilities.
• Studying the functional annotation of genomic elements in relation to Age-Related Eye Disease (ARED).

Strengths

• Identifies 11 genome-wide significant loci for Age-Related Eye Disease.
• Applies multiple transcriptome-wide association approaches for analysis.
• Dataset is openly licensed under CC-BY-4.0.

Limitations

• The dataset is very small at 17.8 KB, indicating limited scope.
• Row count and column-level documentation are absent; field semantics must be inferred after download.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare

Collection Method

Genomic Structural Equation Modeling (Genomic-SEM) and post-processing analysis of Genome-Wide Association Studies.

Freshness

Last updated 2026-05-14 17:48:58; freshness should be verified.