Haemoglobin Genotypes in Ethiopian Crossbred Dairy Cattle

Eyerusalem Tesfaye's study provides haemoglobin (Hb) polymorphism data from 117 Ethiopian Zebu x Holstein Friesian crossbred lactating cows. The dataset contains allelic and genotype frequencies for HbA and HbB, with calculated heterozygosity and inbreeding coefficients across three blood levels and three milkshed locations.

Use Cases

• Analyze genotype frequencies for HbAA, HbAB, and HbBB across blood-level groups to assess Hardy-Weinberg equilibrium.
• Compare heterozygosity values, ranging from 0.03 to 0.18, between HF50% and HF87.5% blood-level subpopulations.
• Examine inbreeding coefficients (FIS) of 0.38 and 0.41 for blood-level and location-based groups to quantify genetic diversity.
• Assess genetic differentiation using FST values (0.06 and 0.01) among subpopulations defined by blood level and location.

Strengths

• Contains data from 117 genetically typed crossbred dairy cows.
• Provides specific allelic frequencies (0.89 for HbA, 0.11 for HbB) and genotype frequencies.
• Includes calculated genetic diversity metrics like heterozygosity and inbreeding coefficients.

Limitations

• Small sample size of 117 cows limits statistical power for broader population inferences.
• Data is geographically limited to three milkshed locations in Ethiopia.
• Dataset scope is narrow, focusing solely on haemoglobin polymorphism at a biochemical level.

Provenance

Source

Eyerusalem Tesfaye via figshare

Collection Method

Haemoglobin typing via horizontal agarose gel electrophoresis on red blood cell lysates.

Time Range

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Freshness

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Geography

Three milkshed locations in Ethiopia: Shashemene, Hawassa, and Dilla.