HTL Epitope Screening Results for a BtHKU5-CoV-2 Vaccine Candidate

20 screened epitopes (8 CTL, 7 HTL, 5 LBL) from the spike glycoprotein of the bat coronavirus BtHKU5-CoV-2, used to design a multi-epitope mRNA vaccine. The dataset, authored by Ningze Zheng and last updated in April 2026, contains results from an immunoinformatics study predicting vaccine antigenicity, immunogenicity, and receptor interactions. The data is shared under a CC-BY-4.0 license on figshare.

Use Cases

• Validate predicted cytotoxic T lymphocyte (CTL) epitopes for vaccine design based on the described screening.
• Analyze helper T lymphocyte (HTL) epitope interactions with MHC molecules as suggested by the study.
• Assess linear B lymphocyte (LBL) epitope binding affinity for antibody response modeling.
• Model molecular docking scenarios between the vaccine construct and Toll-like receptors (TLR2, TLR4).
• Simulate in silico immune responses to the proposed multi-epitope vaccine structure.

Strengths

• Dataset is small (5.5 KB), facilitating quick download and inspection.
• Includes results for 20 distinct epitopes screened from a specific viral protein.
• Provides in silico predictions for antigenicity, immunogenicity, and receptor interactions mentioned in the description.
• Shared under a permissive CC-BY-4.0 license.

Limitations

• Row count and column-level documentation are unknown, limiting suitability assessment.
• All findings are computational predictions; the description notes further experiments are needed for validation.
• The dataset scope is limited to the results from a single, specific vaccine design study.

Provenance

Source

figshare, authored by Ningze Zheng.

Collection Method

Computational screening and immunoinformatics analysis of viral protein sequences.

Time Range

Study likely conducted prior to 2026-04-03.

Freshness

Last updated 2026-04-03 17:42:42; freshness should be verified.

Geography

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