C. albicans Strains: Protein Kinase Essentiality Study Data

A 25.6 KB Excel file lists Candida albicans strains used to assess the essentiality of protein kinases for growth and viability. The dataset, authored by Bernardo Ramírez-Zavala and last updated in April 2026, supports findings on lethal and slow-growth mutants, including the identification of a septation initiation network (SIN) in this pathogenic yeast.

Use Cases

• Identify essential protein kinase genes in Candida albicans based on mutant viability data.
• Study phenotypes of slow-growth mutants like bud32Δ and rio1Δ mentioned in the description.
• Analyze genetic interactions and suppressor mutations, such as those in the Pma1 ATPase.
• Investigate septation and cytokinesis regulation via the identified SIN kinase cascade.

Strengths

• Dataset is small (25.6 KB) and in a standard XLSX format, facilitating quick access and inspection.
• Provides direct experimental data on the essentiality of specific protein kinases in a major fungal pathogen.
• Includes mutants with described terminal phenotypes, such as aseptate hyphae and defective septin organization.

Limitations

• Row count and specific column definitions are unknown, requiring manual inspection after download.
• The dataset's scope is limited to the strains used in a single study, not a comprehensive genomic resource.

Provenance

Source

figshare, authored by Bernardo Ramírez-Zavala.

Collection Method

Likely contains strain identifiers and associated phenotypic data from laboratory experiments using inducible gene deletion.

Time Range

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Freshness

Last updated 2026-04-21 17:46:16.

Geography

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