A dataset from figshare, authored by Juliana B. T. Carnielli and last updated in May 2026, identifies protein kinases in Leishmania parasites as potential drug targets. It describes using a chemical-genetic platform and CRISPR-Cas9 editing to study essential kinases like CRK9 and KKT2. The data is provided in an XLSX file under a CC-BY-4.0 license.
Use Cases
- Identifying covalent kinase inhibitor candidates based on probe SM1-71 reactivity.
- Studying essential kinase functions in Leishmania cell cycle regulation using analog-sensitive mutants.
- Validating potential drug targets like KKT2 and CRK9 for anti-parasitic drug development.
Strengths
- Dataset is openly licensed under CC-BY-4.0.
- The description details a specific chemical-genetic methodology using CRISPR-Cas9.
Limitations
- Column-level documentation is absent; field semantics must be inferred after download.
- Row count is unknown, which may limit suitability assessment.
- The dataset is small (173.2 KB), indicating limited scope.
Provenance
- Source
- figshare
- Collection Method
- Likely generated via mass spectrometry proteomics and CRISPR-Cas9 genome editing as described.
- Freshness
- Last updated 2026-05-13 17:50:35; freshness should be verified.