Trypanosoma Cruzi tRNA-Modifying Enzymes and Orthologs

A collection of lists identifying tRNA-modifying enzymes across eukaryotes and prokaryotes, with specific results for Trypanosoma cruzi. The dataset includes BLAST results, orthologs in Trypanosoma brucei, fitness associations from RIT-seq data, and fold-change values from Ribo-seq data. Herbert Guimaraes de Sousa Silva published this 50.8 KB Excel file on figshare in May 2026.

Use Cases

• Identifying homologs of tRNA-modifying enzymes in T. cruzi based on BLAST results with E-value thresholds.
• Comparing tRNA-modifying enzyme orthologs between T. cruzi and T. brucei.
• Analyzing the fitness impact of tRNA-modifying enzymes during parasite differentiation using linked RIT-seq data.
• Evaluating expression changes of tRNA-modifying enzymes between EPI and MT forms using fold change and p-values from Ribo-seq data.

Strengths

• Data is structured into five distinct lists (A-E) covering enzyme identification, homologs, orthologs, fitness, and expression.
• Includes specific quantitative thresholds (E-value ≤ 1e-10) for homolog identification.
• Links to public RIT-seq data for fitness analysis.

Limitations

• Row count and column-level documentation are unknown; field semantics must be inferred after download.
• The dataset is very small (50.8 KB), indicating limited scope.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare

Collection Method

Likely compiled from bioinformatics analyses including BLAST searches and public sequencing data.

Freshness

Last updated 2026-05-26 17:40:43; freshness should be verified.