Identified SNPs in C. elegans Suppressor Mutants for Neuronal Polarity

14.4 KB of data from a suppressor screen in C. elegans, identifying genetic variants linked to microtubule regulation in neurons. The dataset was created by Sunanda Sharma and last updated on April 15, 2026. It includes variants in tubulin genes and the cytokinesis-associated protein CITK-1/2.

Use Cases

• Identify genetic modifiers of neuronal morphology based on suppressor screen results.
• Analyze the role of tubulin variants in microtubule stability based on the described mec-12 and mec-7 mutations.
• Investigate the non-mitotic function of CITK-1/2 and ASPM-1 homologs in post-mitotic neurons.
• Study the genetic pathway interactions between citk-1/2 and aspm-1 in regulating microtubule plus-end dynamics.

Strengths

• Data is openly available under a CC-BY-4.0 license.
• The research context is described in detail, linking SNPs to a specific neuronal phenotype in C. elegans.
• File is provided in the widely compatible XLSX format.

Limitations

• Dataset is very small at 14.4 KB, indicating limited scope.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

figshare, author Sunanda Sharma.

Collection Method

Data likely generated from a genetic suppressor screen in C. elegans.

Freshness

Last updated 2026-04-15 18:01:08; freshness should be verified.