Immunohistochemical Data on Vitamin D and Propofol Neurotoxicity in Mice

20 pregnant mice were divided into four groups to study the effects of vitamin D on propofol-induced neurotoxicity in offspring. The dataset includes immunohistochemical assessments of the hippocampus and prefrontal cortex at postnatal days 7 and 45, along with behavioral test results. The data was published by Hüseyin Cihat Solmaz on figshare under a CC-BY-4.0 license.

Use Cases

• Analyze the expression levels of inflammatory factors like TNF-α based on immunohistochemistry data.
• Compare apoptotic and anti-apoptotic protein expression (e.g., Bax, Bcl-2) across different treatment groups and brain regions.
• Correlate molecular changes in the hippocampus and prefrontal cortex with behavioral outcomes from open field and elevated plus maze tests.

Strengths

• Data is derived from a controlled animal study with 20 pregnant mice across four distinct treatment groups.
• Includes measurements from two critical brain regions (hippocampus and prefrontal cortex) at two postnatal time points (PN7 and PN45).
• Specific statistical results for key proteins (e.g., TNF-α, Bax, Bcl-2) are reported in the description, indicating a quantitative analysis.

Limitations

• The dataset is very small at 12.4 KB, suggesting limited scope and a small number of observations.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for large-scale statistical modeling.

Provenance

Source

figshare

Collection Method

Experimental data from a controlled animal study involving immunohistochemistry and behavioral tests.

Freshness

Last updated 2026-05-22 18:00:32; freshness should be verified.