Ancylostoma Ceylanicum Hookworm Gene Expression and Immunoregulation Data

565 genes encoding excreted-secreted proteins were identified in the zoonotic hookworm Ancylostoma ceylanicum. The dataset, created by Erich M. Schwarz and last updated in March 2026, compares gene activity in hookworms infecting normal versus immunosuppressed hamster hosts, identifying 1,951 positively immunoregulated genes in mature adult intestinal tissues. This work aims to find potential vaccine targets and understand virulence factors in parasitic nematodes.

Use Cases

• Identify potential hookworm vaccine candidates based on conserved ES gene orthologs mentioned in the description.
• Analyze sex-specific host immune responses based on the male-biased expression of immunoregulated genes.
• Study tissue-specific gene expression patterns based on the 1,670 intestine-biased and 1,196 non-intestine-biased genes.
• Investigate virulence factors based on the enrichment of CAP, ASPR, astacin, and other protein families in immunoregulated ES genes.

Strengths

• Identifies 565 excreted-secreted (ES) protein genes from adult hookworms.
• Compares gene expression across two time points (12 and 19 days post-infection) and two host immune states.
• Highlights 153 ES genes showing positive immunoregulation in mature adult intestine.
• Data is licensed under CC-BY-4.0, allowing for broad reuse.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small at 9.5 KB, indicating limited scope.

Provenance

Source

figshare, authored by Erich M. Schwarz.

Collection Method

Data generated using mass spectrometry and RNA-seq from hookworms infecting hamster hosts.

Freshness

Last updated 2026-03-17 17:35:15; freshness should be verified.