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Description
Single-cell RNA and TCR sequencing data from human tonsil and spleen organoids exposed to Plasmodium falciparum-infected red blood cells. The dataset, 5.5 KB in size, was authored by Kathleen D. Press and published on figshare under a CC-BY-4.0 license, last updated on April 10, 2026. It includes analysis of Vδ2+ γδ T cell frequencies, clonal expansion, and cytotoxic phenotypes in response to malaria parasites.
Use Cases
Analyzing Vδ2+ γδ T cell clonal expansion based on TCR repertoire data mentioned in the description
Investigating cytotoxic T cell phenotypes based on upregulated expression of granzymes and interferon-stimulated genes
Comparing immune responses in malaria-naïve versus malaria-exposed lymphoid organoid models
Validating in vitro organoid findings against tonsil samples from children with asymptomatic parasitemia
Strengths
Data is derived from novel human tonsil and spleen organoid models, as described
Includes single-cell RNA and TCR sequencing analysis, providing multi-modal cellular insights
Published under a permissive CC-BY-4.0 license for reuse
Limitations
Row count and column-level documentation are unknown, which may limit suitability assessment
Dataset is very small at 5.5 KB, indicating limited scope or summary-level data
Column names and sample data are unavailable; field semantics must be inferred after download
Provenance
Source
Kathleen D. Press via figshare
Collection Method
Experimental data from human lymphoid organoids exposed to Plasmodium falciparum, with validation using tonsil samples from Ugandan children.
Time Range
Experimental timeframe not specified in metadata.
Freshness
Last updated 2026-04-10 18:00:27
Geography
Organoid donors described as malaria-naïve; validation samples from Ugandan children.
Data is in XLS (Excel) format; requires compatible software to open.