<p>Innate cell panel.</p>

Single-cell RNA and TCR sequencing data from human tonsil and spleen organoids exposed to Plasmodium falciparum-infected red blood cells. The dataset, 5.5 KB in size, was authored by Kathleen D. Press and published on figshare under a CC-BY-4.0 license, last updated on April 10, 2026. It includes analysis of Vδ2+ γδ T cell frequencies, clonal expansion, and cytotoxic phenotypes in response to malaria parasites.

Use Cases

• Analyzing Vδ2+ γδ T cell clonal expansion based on TCR repertoire data mentioned in the description
• Investigating cytotoxic T cell phenotypes based on upregulated expression of granzymes and interferon-stimulated genes
• Comparing immune responses in malaria-naïve versus malaria-exposed lymphoid organoid models
• Validating in vitro organoid findings against tonsil samples from children with asymptomatic parasitemia

Strengths

• Data is derived from novel human tonsil and spleen organoid models, as described
• Includes single-cell RNA and TCR sequencing analysis, providing multi-modal cellular insights
• Published under a permissive CC-BY-4.0 license for reuse

Limitations

• Row count and column-level documentation are unknown, which may limit suitability assessment
• Dataset is very small at 5.5 KB, indicating limited scope or summary-level data
• Column names and sample data are unavailable; field semantics must be inferred after download

Provenance

Source

Kathleen D. Press via figshare

Collection Method

Experimental data from human lymphoid organoids exposed to Plasmodium falciparum, with validation using tonsil samples from Ugandan children.

Time Range

Experimental timeframe not specified in metadata.

Freshness

Last updated 2026-04-10 18:00:27

Geography

Organoid donors described as malaria-naïve; validation samples from Ugandan children.