Urinary Tract Infection Profiles in Heart Failure Patients Using SGLT2 Inhibitors

Fifteen percent of urine samples from 138 heart failure patients on SGLT2 inhibitors showed significant bacterial growth. Researcher Julieth Kaaya collected this data via structured questionnaires and lab tests at a Tanzanian cardiac institute from March to June 2024.

Use Cases

• Identify risk factors like age >60 years and female sex for UTI prediction in this patient cohort.
• Analyze antimicrobial susceptibility patterns, such as high resistance to ampicillin and susceptibility to nitrofurantoin.
• Model the association between SGLT2 inhibitor use duration (≥4 months) and UTI incidence using regression techniques.
• Profile uropathogen distribution, with Escherichia coli comprising 50% of isolates.

Strengths

• Data includes 138 patient urine samples with detailed culture results.
• Antimicrobial susceptibility testing was performed per CLSI 2024 guidelines.
• Analysis includes adjusted prevalence ratios (aPR) for specific risk factors.

Limitations

• Small sample size of 138 patients limits statistical power and generalizability.
• Data is from a single institute in Tanzania, introducing geographic bias.
• Temporal coverage is limited to a 4-month cross-sectional period.

Provenance

Source

Julieth Kaaya via figshare.

Collection Method

Hospital-based cross-sectional study using questionnaires, medical records, and semi-quantitative urine culture.

Time Range

March to June 2024.

Freshness

Data collected up to June 2024.

Geography

Jakaya Kikwete Cardiac Institute (JKCI), Tanzania.