Mouse Histone Lysine Lactylation Sites from Mass Spectrometry

Mass spectrometry results identify lactylation sites on histone proteins across all mouse histone isoforms. The dataset, 643.4 KB in size, was created by Mohita Gaur and last updated in April 2026. It contains search results for lysine lactylation, annotated with a +72.021 Da mass shift.

Use Cases

• Validate lactylation site predictions by cross-referencing identified sites and modification annotations.
• Analyze the distribution of lactylation modifications across different histone isoforms listed in the results.
• Use the annotated mass shift of +72.021 Da to calibrate or train mass spectrometry search algorithms for this modification.
• Correlate identified lactylation sites from this dataset with other epigenetic marks or functional genomic data.

Strengths

• Data is focused on a specific, novel histone modification (lysine lactylation) with a defined mass shift.
• Results are derived from a search through the entire mouse histone database, providing isoform-level context.
• Dataset is openly shared under a CC-BY-4.0 license, facilitating reuse.

Limitations

• The dataset is small (643.4 KB), indicating a limited scope or sample size for the mass spectrometry run.
• The number of identified sites (rows) and supporting spectral evidence is not specified.
• Data is specific to mouse histones, limiting direct applicability to other organisms without comparative analysis.

Provenance

Source

Figshare, authored by Mohita Gaur.

Collection Method

Mass spectrometry analysis with database searching, using lysine lactylation (+72.021 Da) as a variable modification.

Freshness

Last updated in April 2026, indicating recent data generation.