Laboratory Values from NTCP/OATP Inhibition Study in Atherosclerotic Mice

56 female ApoE⁻/⁻ mice were treated for four weeks to study bile acid transport inhibition. Plasma bile acids, lipids, and atherosclerotic lesion metrics were measured at sacrifice. Jonas Rusnak published this dataset on figshare in May 2026.

Use Cases

• Analyze plasma bile acid concentration changes based on transporter inhibition treatments described.
• Compare atherosclerotic lesion size and macrophage content across different treatment groups.
• Investigate the relationship between bile acid levels and plaque composition modulation.
• Model additive effects of dual NTCP and OATP inhibition on biochemical parameters.

Strengths

• Data originates from a controlled experiment with 56 mice and four distinct treatment groups.
• Specific dosage details are provided (5 mg/kg bulevirtide, 20 mg/kg rifampicin).
• Key outcome metrics include plasma cholesterol, LDL, HDL, triglycerides, bile acids, and lesion analysis.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is 5.5 KB, indicating a very limited scope of data.

Provenance

Source

figshare

Collection Method

Experimental study measuring plasma bile acids, lipids, and lesion size in mice.

Freshness

Last updated 2026-05-26 17:27:12; freshness should be verified.