Lesion Area and Mac-2 Measurements from Atherosclerosis Mouse Study

A 2026 dataset by Jonas Rusnak contains measurements from a four-week pharmacological study in mice. The data likely includes plasma bile acid concentrations, lipid levels, atherosclerotic lesion size, and macrophage content quantified by Mac-2 immunohistochemistry. It originates from a study investigating the impact of NTCP and OATP inhibition on atherosclerosis in ApoE-deficient mice.

Use Cases

• Analyzing the relationship between bile acid levels and macrophage content in atherosclerotic lesions based on plasma bile acid concentrations and macrophage-to-lesion area ratio mentioned in the description
• Comparing the effects of single versus dual transporter inhibition on biological markers based on treatment groups (bulevirtide, rifampicin, combination)
• Investigating plaque composition modulation as a potential therapeutic mode of action based on the association of bile acid with macrophage content reduction

Strengths

• Data is associated with a specific, controlled four-week animal study with 56 female ApoE-deficient mice
• Includes multiple measured endpoints: plasma bile acids, lipids, lesion size, and macrophage content
• License is CC-BY-4.0, allowing for broad reuse

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• The dataset is very small (5.5 KB), indicating limited scope

Provenance

Source

Jonas Rusnak via figshare

Collection Method

Data likely gathered from a controlled laboratory experiment measuring plasma biomarkers and histological analyses in mice.

Time Range

Study duration was four weeks; dataset publication date is 2026.

Freshness

Last updated 2026-05-26 17:27:13; freshness should be verified