Hepatitis C Surrogate Virus Cell Culture Mutations List

A list of cell culture–adaptive mutations identified for a reporter hepatitis C virus surrogate. Yasunori Akaike compiled this dataset, which is available as a 5.5 KB Excel file last updated in April 2026.

Use Cases

• Analyze mutation patterns in the NS5A domain III region from reporter virus passaging.
• Correlate specific adaptive mutations with HiBiT reporter gene loss or stability.
• Identify genomic sites prone to variation during in vitro cell culture infection experiments.
• Compare mutation lists from immunodeficient mouse models to in vitro findings.

Strengths

• Data is derived from a published virological study establishing a novel reporter virus platform.
• Released under a permissive CC-BY-4.0 license for reuse.
• File is a small 5.5 KB Excel spreadsheet for easy inspection.

Limitations

• Dataset scale is extremely limited at 5.5 KB, suggesting a short list of mutations.
• No row count or sample data is provided to assess comprehensiveness.
• Focus is narrow, specific to a single rat hepacivirus (NRHV1) model.

Provenance

Source

figshare, authored by Yasunori Akaike.

Collection Method

Mutations likely identified via circular polymerase extension reaction (CPER) and sequencing of recovered virus.

Time Range

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Freshness

Last updated date is in the future (2026-04 -08), indicating a planned update or data embargo.

Geography

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