Enriched Gene Rankings with Combined Score and Protein Interaction Clusters

A table of genes ranked by a combined score derived from -log10 FDR and log2 fold change, created by Stefano Sellitto and last updated on 2026-04-20. The dataset includes genes with multiple sgRNAs in top rankings and highlights STRING-derived protein-protein interaction clusters. It is provided as a 178.6 KB XLSX file under a CC-BY-4.0 license.

Use Cases

• Prioritizing candidate genes for functional validation based on the combined enrichment score.
• Identifying protein-protein interaction networks among enriched genes using the highlighted STRING clusters.
• Filtering for genes with multiple high-ranking sgRNAs to increase confidence in screening hits.
• Comparing gene essentiality classifications between different time points in a CRISPR screen.

Strengths

• Provides a combined statistical score integrating FDR and fold change for gene ranking.
• Highlights protein-protein interaction clusters derived from the STRING database.
• Explicitly indicates genes classified as non-essential in a specific time-point comparison.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for large-scale analysis.
• The 178.6 KB file size suggests a limited scope, likely covering a focused gene set rather than a genome-wide screen.

Provenance

Source

figshare

Collection Method

Likely derived from a CRISPR genetic screen analysis, with enrichment scores calculated and protein interactions mapped.

Time Range

The temporal coverage of the underlying experiment is not specified.

Freshness

Last updated 2026-04-20 17:40:25; freshness should be verified.

Geography

Spatial coverage is not applicable for this genomic data.