Luciferase reporter gene sequence data from a study screening miRNAs involved in sensorineural hearing loss. Pingping Meng published the 5.5 KB Excel file on figshare in May 2026. The research identified miR-224-5p, miR-339-5p, and miR-1198-5p as key regulators of neurofilament protein expression.
Use Cases
- Validate miRNA binding predictions based on luciferase reporter assay sequence data
- Design follow-up experiments targeting miR-224-5p, miR-339-5p, and miR-1198-5p based on screening results
- Analyze gene expression regulation mechanisms in cochlear tissues based on described neurotrophic factor Neuritin
- Assess therapeutic potential of miRNA inhibitors for sensorineural hearing loss based on in vivo experimental results
Strengths
- Data is openly licensed under CC-BY-4.0
- Research identified three specific miRNAs (miR-224-5p, miR-339-5p, miR-1198-5p) with validated in vivo effects
- File is available in a common, accessible format (XLS)
Limitations
- Row count is unknown, which may limit suitability assessment
- Column-level documentation is absent; field semantics must be inferred after download
- Dataset is very small (5.5 KB), indicating limited scope
Provenance
- Source
- figshare
- Collection Method
- Generated from a study using high-throughput sequencing and bioinformatics analysis on a mouse model of SNHL.
- Freshness
- Last updated 2026-05-21 17:30:49; freshness should be verified