Malaria-Naïve Donor Tonsil and Spleen Organoid Data

A study by Kathleen D. Press uses human tonsil and spleen organoids from malaria-naïve donors to investigate immune responses to Plasmodium falciparum. The dataset, last updated in April 2026, includes observations on Vδ2+ γδ T cell frequencies and clonal expansion following parasite exposure. The work also includes validation data from tonsils of Ugandan children with asymptomatic parasitemia.

Use Cases

• Analyzing Vδ2+ γδ T cell frequency changes based on exposure to infected red blood cells.
• Studying clonal expansion and cytotoxic phenotypes in T cells based on single-cell RNA/TCR sequencing results.
• Comparing T cell responses in organoid models to tonsil samples from children with asymptomatic parasitemia.
• Investigating the effect of malaria pre-exposure on recall responses to influenza vaccine.

Strengths

• Data is derived from a novel human tonsil and spleen organoid model for studying lymphoid tissue immunity.
• Includes validation from real-world samples: tonsils from Ugandan children with asymptomatic parasitemia.
• Released under the permissive CC-BY-4.0 license.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small at 5.5 KB, indicating limited scope.

Provenance

Source

figshare, authored by Kathleen D. Press.

Collection Method

Experimental data from organoid models and analysis of human tonsil samples.

Time Range

The study timeframe is not specified.

Freshness

Last updated 2026-04-10 18:00:23.

Geography

Includes data from malaria-naïve donors and Ugandan children.