Rat Osteoarthritis Treatment Histopathology Scores and Biomarker Data

Four weeks of experimental data from a rat osteoarthritis model study. The dataset contains Mankin's scores from histopathological examination and serum biomarker levels for inflammatory factors. Mingming Pan authored this dataset, which was last updated in April 2026.

Use Cases

• Compare Mankin's scores across treatment groups to assess cartilage damage.
• Analyze correlations between serum levels of TNF-α, COX-2, IL-1β, CTX-II and histopathological outcomes.
• Evaluate treatment efficacy by comparing weekly plantar mechanical pain threshold (MPT) measurements.
• Model the relationship between weekly body weight, food intake, water intake and treatment response.

Strengths

• Data from a controlled 4-week animal study with multiple measurement timepoints.
• Includes quantitative histopathology scores (Mankin's score) and multiple serum biomarker measurements.

Limitations

• Very small dataset at 5.5 KB, indicating limited sample size.
• Data is specific to a single rat model of osteoarthritis, limiting generalizability.
• Contains only summary-level group data, not individual animal records.

Provenance

Source

Mingming Pan via figshare.

Collection Method

Data collected from a controlled laboratory experiment on rats with induced osteoarthritis.

Time Range

Experimental period spans 4 consecutive weeks.

Freshness

Last updated in April 2026.